A microcosm of what went wrong with the industrial revolution:
Calhoun’s Mouse Utopia experiment
Bruce G Charlton MBBS (Hons), MD (Ncle); MA (Dunelm)
Reader in Evolutionary Psychiatry, Newcastle University, England; Visiting Professor of Theoretical Medicine, University of Buckingham, England
The so-called ‘Mouse Utopia’ experiment was conducted from 1968 by John B Calhoun
http://en.wikipedia.org/wiki/John_B._Calhoun
Four healthy breeding pairs of mice were allowed to reproduce freely in a 'utopian' environment with ample food and water, no predators, no disease, comfortable temperature – a near as possible ideal conditions and space. What happened was described by the author in terms of five phases: establishment, exponential growth, growth slowing, breeding ceases and population stagnant, population decline and extinction:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1644264/pdf/procrsmed00338-0007.pdf
Phase A - 104 days - establishment of the mice in their new environment, then the first litters were born.
Phase B - up to day 315 - exponential population growth doubling every 55 days.
Phase C - from day 315-560 population growth abruptly slowed to a doubling time of 145 days.
Phase D - days 560-920; population stagnant with births just matching deaths. Emergence of many pathological behaviours.
Terminal Phase E - population declining to zero. The last conception was about day 920, after which there were no more births, all females were menopausal, the colony aged and all of them died.
To summarise – when four breeding pairs of mice were allowed to reproduce under ideal ‘utopian’ conditions, the colony entirely ceased to breed after three years, and then went extinct.
Interpreting the demise of Mouse Utopia
The main fact about Mouse Utopia, was that despite everything possible being done to create ideal biological conditions; the mouse colony rapidly declined and became entirely extinct. This was a very surprising outcome, biologically; and implies that some very major factor about the basic requirements or behaviour of the mice was neglected.
The Mouse Utopia experiment is usually interpreted in terms of social stresses related to 'over-population'; that crowding generated pathological behaviours and a loss of the will to reproduce. But this seems, very obviously – I would have thought – an incorrect explanation; because 1. The mouse population never actually became crowded, 2. The suppression of breeding happened very quickly, and never recovered even after the population declined rapidly and crowding was reduced, and 3. the population rapidly became extinct.
Michael A Woodley suggests that what was going on was much more likely to be mutation accumulation; with deleterious (but non-fatal) genes incrementally accumulating with each generation and generating a wide range of increasingly maladaptive behavioural pathologies; this process rapidly overwhelming and destroying the population before any beneficial mutations could emerge to 'save; the colony from extinction.
So the bizarre behaviours seen especially in Phase D - such as the male 'beautiful ones' who appeared to be healthy and spent all their time self-grooming, but were actually inert, unresponsive, unintelligent and uninterested in reproduction - were plausibly maladaptive outcomes of a population sinking under the weight of mutations.
Why mutation accumulation?
The reason why mouse utopia might produce so rapid and extreme a mutation accumulation is that wild mice naturally suffer very high mortality rates from predation. Because wild mice are so short-lived, mice are not 'built to last' and have the reputation of being unusually-prone to produce new deleterious mutations (and are therefore extremely prone to cancer, and susceptible to carcinogens - which is why mice are used to test for carcinogens).
Thus mutation selection balance is in operation among wild mice, with very high mortality rates continually weeding-out the high rate of spontaneously-occurring new mutations (such reproductive exclusion of the 'less fit' being especially strong among males, see below) - with typically only a small and relatively mutation-free proportion of the (large numbers of) offspring surviving to reproduce; and a minority of the most active and healthy (mutation free) males siring the bulk of each generation.
However, in Mouse Utopia, there is no predation and all the other causes of mortality (eg. Starvation, violence from other mice) are reduced to a minimum - so the frequent mutations just accumulate, generation upon generation - randomly producing all sorts of pathological (maladaptive) behaviours.
The danger of mutational meltdown
Extinction due to relaxed selection leading to rapid mutation accumulation is called ‘mutational meltdown’.
It happens because, in addition to the problem of mutation accumulation by relaxation of selection, when a population has begun shrinking, there is an increasing danger of extinction due to a positive feedback cycle. Deleterious mutations accumulate so rapidly that they overwhelm a population before it can evolve an escape – as the population shrinks so it becomes less and less likely to ‘randomly’ generate a compensatory beneficial mutation that might rescue it from extinction.
http://en.wikipedia.org/wiki/Mutational_meltdown
Mutational meltdown was first described as a threat for small populations of asexual organisms; later the phenomenon was described in sexual organisms, and then fond to occur in large populations. Therefore, mutational meltdown has gone from being a specific case to probably a universal possibility. And thus a possibility in humans.
The unusual twist with modern humans is that native populations in developed countries have begun falling (rapidly) over the past several decades apparently due to chosen sub-replacement fertility, and probably before mutation accumulation had reached a level sufficient biologically to suppress fertility.
In other words psychological factors have anticipated biological factors - and presumably both psychological and biological population decline will combine to increase the degree of reduced fitness resulting from mutation accumulation.
This will probably have increased the risk of mutational meltdown, and of extinction.
Modern England as Mouse Utopia?
If we look at the Mouse Utopia experiment and try to fit the history of modern England into it
http://en.wikipedia.org/wiki/Demographics_of_England
There could be an inflection point in 1921 when English population growth suddenly slowed - somewhat like the transition from Phase B to C in the mouse utopia graph (page 83)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1644264/pdf/procrsmed00338-0007.pdf
Then the plateau Phase D - where births just replace deaths - was reached in the 1970s
http://en.wikipedia.org/wiki/Demographics_of_the_United_Kingdom#Vital_statistics_1960_.E2.80.93_2013
Which perhaps means the next phase would be the Terminal Phase E (among the native population - disregarding immigrants) with fewer births than deaths dwindling to zero live, births and escalating median age, until eventually ‘all’ women are aged beyond the menopause at which point extinction (of the native population) is inevitable.
Well, this isn't really comparing like with like! - and the whole picture is muddied by increasing medical capability and cossetting, which has radically reduced deaths from infectious disease (the main cause of mortality); and keeps infants and the elderly alive in circumstances which would previously have been fatal - but maybe gives us clues of what to look-out-for; assuming that the demise of Mouse Utopia was indeed substantially due to mutation accumulation.
Possible timescale for human extinction
If humans are recapitulating mouse utopia, what might be the approximate timescale for extinction?
As far as I can gather, mice are fully ready to reproduce at about 4 months, so the average generation time is probably about 5 months which is about 150 days.
So, starting with 104 days as zero - when reproduction in Mouse Utopia began; we can convert the above timings into mouse generations
Phase B exponential growth doubling every 55 days lasted 201 days, = 1.3 mouse generations.
Phase C exponential growth doubling every 145 days lasted a further 245 days = 1.6 mouse generations.
So population growth phase in utopian conditions lasted only 3 mouse generations.
Phase D of population stagnation phase lasted a further 360 days = 2.4 mouse generations
Therefore, Terminal Phase E the last conception (and de facto inevitable extinction) was 816 days after breeding commenced = 5.4 mouse generations.
Human generations are conventionally 25 years, although these have slowed to about 30 years in Western countries in the past several decades - but let us therefore give two values - one for 25 year, and the other for 30 year human generations.
If we start at 1850 as the date when the Industrial Revolution seems to have become certainly established and child mortality rates began to drop rapidly (from more than 60 percent to about 1 percent), and start counting generations from that point, and if humans were made like mice (which they are not!)...
We would then predict that human population growth phase (B & C) would last three generations up to 1925-1940
And the stagnation phase (D) for another 2.4 generations - with 5.4 human generations taking us up to 1985-2012.
Well, clearly English people did not stop conceiving four years ago, because babies are still being born to native English - albeit not at a high rate!
I have guesstimated above that the English situation was that the slower growth Phase C began in about 1920 (not about 1880) and the plateau phase began in about 1970) not 1930-ish
So maybe England is lagged about 40 years (or about 1.5 generations) behind Mouse Utopia , because 1. we are not mice, and 2. our mouse utopia emerged only incrementally – moving from the upper to the lower classes; and was probably not complete until about 1950.
So we do not need to worry about mutational meltdown and de facto extinction (i.e. the final English child of English-descended parents being conceived) for, oh, another thirty or forty years!...
Longevity versus fitness
In the late phases of the mouse utopia experiment the birth rate dwindled to zero - but there was a plateau phase when the population numbers remained approximately static because the fewer mice were being born but more mice were living to an extreme old age – a lifespan of four years and longer, which is considerably older than mice would expect to live in the wild.
Yet these mice were grossly abnormal, indeed pathological, in their behaviour. - in particular suffering what might be termed psychiatric abnormalities that impaired social interaction (and reproduction) including a strange narcissism in some male mice (the 'beautiful ones') which looked like superb physical specimens but did not mate.
So we find on the one hand a combination of evidence of cumulative disease, initially manifested in the realm of behaviour - yet on the other hand an ageing population with some animals having a very long life span.
My interpretation is that an increasing average lifespan cannot be interpreted as improving fitness - indeed increasing lifespan is compatible with a severe reduction in functional behaviour; especially when functionality is defined 'biologically' in terms of reproductive success (having sufficient viable offspring to maintain population numbers, and potentially amplify the population when conditions permit).
In Britain in recent decades there has been a large increase in average lifespan (among the native population), including several-fold increases in the length of survival of many groups of ill people. For example, elderly people with moderate to severe dementia may now live for many years, whereas thirty or forty years ago such a diagnosis was regarded as being rapidly fatal within months and less than two years. (And taking into account that modern English average life expectancy is about 80 years – an age at which about 20 percent of people have measurable dementia).
There is no doubt that modern people have been, and are being, misled by the increase in lifespan - and superficial appearances of youthfulness - into assuming that population health is improving; when in biological terms what matters is the ability to survive and reproduce under given conditions. Only if modern people - in particular those of reproductive and productive age - were put into the same kind of harsh, high mortality-rate environment that people of the past lived-in, would we know whether they really do have better functionality.
For example, in hunter gatherer societies those who lack mobility will, sooner or later, necessarily be left to die. In agricultural societies, the struggle for survival was extremely severe and the shortage of food, poor housing, and high prevalence of severe infectious diseases meant that the mortality rate among the elderly was much higher.
But modern societies shelter pretty much everybody from exposure to extreme heat or cold, dehydration, starvation, epidemic infectious disease and violence; plus there are several life-extending treatments of chronic medical conditions (such as high blood pressure) which would soon cripple or kill without continued medication and management.
Therefore, many people of much-reduced functionality who would been unable to survive in historical societies, are currently kept alive for many extra decades in modern societies - with all appearances of reasonably good health... except for behavioural pathologies and sub-fertility.
My point is that modern people may be much less biologically fit than they think they are; and that if societal conditions reverted towards those of historical agrarian societies, or hunter gatherer conditions, their low fitness and inability to survive would become very obvious.
Perhaps the increasingly elderly individuals of the terminal phase of mouse utopia may have congratulated themselves on the success of the experiment, and that mice had attained a more comfortable and compassionate level of social organization than in any previous society.
And then they died out; every last one of them.
Nonetheless, I draw the following lessons.
1. Assuming the decline and extinction of mouse utopia was due to mutation accumulation leading to mutational meltdown - then it happened very quickly indeed: only 5.4 mouse generations to the final conception, with half of that being stagnation.
2. The decline in rate of population increase after only 1.3 mouse generations suggests that the effect of relaxed natural selection and mutation accumulation leads to genetic damage immediately, in the very first generation.
3. Although humans (maturing over 14 years and with a natural life expectancy about 70 years) are built to last longer than mice (maturing over 4 months and living about 2 years) - this may mean that humans are actually more vulnerable to mutation accumulation - because we have a more prolonged and multi-phasic development and depend on extremely-complex brains supporting extremely complex behaviours; which depend on many genes to create and to sustain. Complex social and sexual adaptations are, in other words, large mutational targets – susceptible to damage from many mutations.
4. In mouse utopia, the mouse environment, shelter, food, hygiene etc were all managed by humans - and did not depend on the mice doing anything much for themselves except eat, sleep, fight, groom and reproduce (until they altogether lost interest in sex) - but humans depend on other humans for survival. But when the human population is damaged from mutation accumulation, there will be no external experimenters to ‘look after’ the increasingly-dysfunctional humans – and this will tend to destroy the 'utopian' environment. In other words, there will be a combination of an increasingly dependent population with a reducingly-capable population.
If this destruction is severe enough and comes early enough- then mutational meltdown will be avoided; because harsher natural selection (from the less capable ‘caring’ population) will purge the mutationally-loaded population to prevent it from breeding (and worsening the problem). But if there is a generational lag - and utopia is maintained for sufficiently long that further mutational damage to younger generations continues to accumulate rapidly - then this will hasten the meltdown and extinction; because by the time utopia comes to an end, the younger generations will be unfit to survive the harsher conditions which are the best they can themselves manage.
That is, the younger generations will become too unfit even to care for themselves at a bare minimum level while also being able to reproduce with genetically-viable offspring, and to raise them to independence – at which point extinction is inevitable. The ‘plateau’ phase is when a generation is born that can just-about keep itself alive and functioning, but not able raise any of its (even less-fit) offspring. Eventually, a generation is born that is not even capable to sustaining itself, and the die-off will then be very rapid.
What signs should we look for in monitoring mutation accumulation?
The first signs of mutation accumulation would probably be de-differentiation/ loss of adaptations - especially in social and sexual functioning. These would affect general intelligence 'g' (because g is a fitness measure), and adaptive social and sexual functioning (because these are subtle/ advanced adaptations which are damaged by even slight illness, intoxication, and functional or structural brain impairments).
http://iqpersonalitygenius.blogspot.co.uk/2012/08/objective-and-direct-evidence-of.html
http://iqpersonalitygenius.blogspot.co.uk/2014/03/further-evidence-of-significant-slowing.html
I think evidence consistent with both lowered intelligence and also impaired adaptive social functioning can be observed in the report of Mouse Utopia. The reduced fertility in Mouse Utopia is perhaps also related to impaired drive/ motivation - as well as ineffective drive/ motivation (due to loss of functional adaptations).
I general, I think loss of adaptive functionality is what should be looked-for with mutation accumulation (i.e. adaptive behaviours knocked-out or damaged or distorted) as the first and most sensitive changes; rather than weird new behaviours. Specifically:
1. The social domain - first subtle, then gross impairments of adaptive social interactions
2. The sexual domain - first subtle, then gross impairments of adaptive sexual interactions
...bearing in mind that 'adaptive' means tending to enhance reproductive success.
I suggest social and sexual functioning, since these are the areas which I think are the most sensitive to brain impairments; at least that seems to be the situation in neurological and psychiatric disease.
My observation has been that when there is almost any significant degree of neurological or psychiatric disease, even the slightest; social and sexual domain functioning can usually be detected as having been impaired, by those who best knew the patient before he suffered illness.
Psychiatric aspects of Mouse Utopia
In The Narrow Roads of Gene Land Volume 2, the great evolutionary theorist WD Hamilton partially described that world in a chapter entitled The Hospitals are coming, and that is perhaps a good starting point - the idea that everyone will be damaged and most will be sick, in one way or another; so that life will resemble a hospital in which (some of) the less-sick (or the damaged but not-yet sick) tend the more-sick, as best they may - in intervals between doing whatever it takes to stay alive.
This is not by any means an unusual or unprecedented situation for humans through much of the history of the species. For much of the time, Malthusian mechanisms have been in force, and populations have been limited by various combinations of starvation and infectious disease. Infections - in particular - have sometimes been endemic at a high prevalence, so that the majority or even all of the population might be suffering from, be affected by, some chronic parasitic disease (malaria and bilharzia are examples) - but at a relatively low degree of severity.
And with respect to the Mouse Utopia society being a Hospital, it is important to recognize that much of the pathology will be psychiatric rather than physical - this can be seen from the fact that the problems of the original Mouse Utopia were most behavioural rather than physical; and it follows from the fact that the highly complex human brain is exceptionally sensitive to random mutational damage.
Intelligence is probably damaged by mutation accumulation in an incremental and quantitative fashion - the more mutations, the more the lowering of intelligence. Therefore, decline of intelligence as mutations accumulate is likely to be relative smooth (rather than step-like). But intelligence is 'general' intelligence, and is unusual in being a general attribute of cognitive function – probably sustained by small effects of a large number of individual genes. By contrast, most psychological functions are specific; and genetic damage is likely to be more qualitative and either step-like, or all-or-nothing.
What I think would happen, is that accumulating mutation damage would most likely show-up as varieties of specific brain functional damage leading to a wide range of specific behavioural impairments of a social and sexual type (differing between individuals due to random mutations striking unpredictably at a wide range of individual genes) - in a context of progressively declining intelligence.
The kind of damage I am talking about represents a decline in ‘fitness’ – ie. a decline in the functional adaptation of the human organism to its environment (its sexual, social and surrounding environment): a loss of effective functionality. This represents a decline in absolute fitness, but not just relative fitness. It is a also a decline in group fitness - ultimately in species fitness.
If fitness is measured in terms of the capacity to raise sufficient viable offspring in a given environment; then the sexual and social changes induced by mutation accumulation will be such as to reduce the probability of doing this: partly by damage causing reduced brain processing speed and efficiency (detectable as reduced intelligence) and partly by damage causing specific functional impairments (detectable as sexual and social pathologies).
These impairments would presumably include a decline in motivation – reduced motivation to engage in effective reproductive behaviours, reduced interest in sex liable to lead to reproduction, reduced motivation to procreate, to care for and rear children etc. There is certainly abundant evidence of such changes in modern developed societies, such as England.
In sum, in a broad-brush interpretation of the evidence, it looks very much as if England specifically, and all other developed nations to a greater or lesser extent, are recapitulating the Phases of Mouse Utopia – leading towards extinction, or something close to it.
**
Acknowledgements: It was Michael A Woodley of Menie who informed me of the Mouse Utopia experiment, and made the interpretation of its outcome in terms of mutation accumulation.
See also: http://charltonteaching.blogspot.co.uk/2016/12/was-human-mouse-utopia-inevitable-no.html
*****
Was Human Mouse Utopia necessary and inevitable?
http://charltonteaching.blogspot.co.uk/2016/12/mouse-utopia-and-dysfunction-and.html
No - because there are other forces at work in biology (although denied by mainstream biology) that can in principle overcome such tendencies as mutation accumulation and de-differentiation. As I explained in a paper earlier this year:
https://thewinnower.com/papers/3497-reconceptualizing-the-metaphysical-basis-of-biology-a-new-definition-based-on-deistic-teleology-and-an-hierarchy-of-organizing-entities
A comprehensive biology would focus on development, not natural selection, as its primary mode of explanation; and there are integrative and purposive factors at work, that explain (for example) the origins of life, major transitions of evolution, and sexual reproduction. Such purposive forces could, presumably, operate in a predictive, long-termist and group-benefiting way to overcome the cumulative genetic damage envisaged in Mouse Utopia.
But I do not believe this happened. Mouse Utopia has happened to humans, and continues to happen; and the purposive and integrative forces have not been mobilised. The purposive forces that shape biology were not, in fact, deployed - they did not choose to deploy. The 'natural' tendency to destruction was allowed...
Mouse Utopia was the choice of modern Man - Modern Man, in effect, decided to define his 'utopia' as a world much like Mouse Utopia: a world of hedonic materialism - that is a world dedicated to comfort, convenience, and pleasure.
Modern Man got what he wanted, but the consequence will be destruction of his civilisation.
Because there is a deeply sinister aspect to the modern condition, such that it must be brought to an end. In effect, I am saying that modern humans chose Mouse Utopia as its ideal back around 1800 and have stuck to that decision ever since; the led to Mouse Utopia, and Mouse Utopia leads naturally to mutation accumulation, loss of fitness, reproductive decline and extinction. All this was allowed to happen because the alternative would be much worse.
From a divine perspective, modernity has been a colossal disaster. Not so much for the mass slaughter of wars, nor even from the even greater sufferings and slaughter of the exterminations practised by materialistic, hedonic, atheistic Left wing dictatorships (Lenin, Stalin, Hitler, Mao, Pol Pot, Kim Jong-il etc) - but from the perspective of the mass self-chosen damnation of souls.
I have said many times that we live - now, in The West - in the most evil time and place ever; and I mean this quite factually and objectively. Never before has there been (so far as we know) any human society in which The Good has been so comprehensively subverted, and indeed inverted.
To an astonishing, and ever increasing extent we regard virtue as evil; wickedness (short-termist, selfish, manipulative pleasure seeking) as virtue; we do not even attempt to be truthful but revel in deceptions, and misleading; we not not attempt to create beauty but instead mar it and claim that the disgusting and soul-destroying is true beauty.
http://thoughtprison-pc.blogspot.co.uk
Westerners live in a fake world of the mass media, and are addicted to this world - and this world is the focus and major source of subversion and inversion.
In sum, modern Man is very deep in evil, and wants more evil - therefore it is important that modern man be stripped of his power and capability since he will use it, overall, for ill.
In this sense, Mouse Utopia is the saving of the world from a spiritual fate worse than death: worse than most people believe or can even imagine. Because if modern Man retained the capabilities he once had, he would have deployed this creativity to monitor, manipulate, exploit and torment - his objectives would be (as they are, and have been for several decades) to spread fear, resentment, and despair - and induce an active loathing of salvation (so that - eventually - Christianity is rejected not because it is believed to be false - but because it is known to be true; but revolting, oppressive and immoral).
In sum, modern Man chose Mouse Utopia when he chose materialism (and rejected the challenge of of developing as Romantic, Imaginative, Intuitive Christianity as envisaged embryonically by Goethe, Blake, Coleridge and Wordsworth). The biological consequences of Mouse Utopia could have been prevented, but were not; and - unless there is a change of heart, repentance, and a new spirit in The West - Mouse Utopia will be allowed to destroy the power and capability of The West - for its own good, and the good of humanity in general; because the alternative is so utterly appalling: the Transhumanist nightmare, a living Hell.
http://charltonteaching.blogspot.co.uk/2016/12/what-is-biggest-threat-to-western-man.html
Does Mouse Utopia lead to greater spiritual danger?
If Mouse Utopian conditions lead to a reduced adaptiveness for humans - reduced intelligence, impaired instincts, damage to sexual and behavioural functionality, mass illness and premature death; then is this likely to change the spiritual condition of Man?
Mouse Utopia would be expected to lead to a collapse of the economy, and a massive (talking billions*) decline in population, and all sorts of other material disasters - but from a Christian perspective, how might things play-out?
My guess would be that spiritually things would overall improve, not decline; since Christian faith does not need high intelligence, fitness, adaptiveness, long life, or anything else. Young children, the simple minded, the crippled and sick - such persons have been and can be Christians as good as any - and better than most.
A further factor to consider is that here and now, in the West - two hundred years after the onset of the industrial revolution, and beneficiaries of decades of peace, comfort, prosperity and longevity - we have the least spiritual and most systematically evil society in the history of the world.
Here and now we dwell in a society so evil that it not only fails to recognise the reality-of, or distinguish-between, Good and evil but actually inverts them.
A society which mobilises the state, educational systems, and the mass media to advocate more and new inversions of Good; a society that creates official propaganda for inversions of truth, beauty and virtue; laws to implement inversion, which bribes and coerces the mass population into acknowledging inversion.
And this modern world was the product of genius - the genius of European peoples who discovered, devised, invented and made the theories, artifacts and systems upon which the modern anti-Good world depends. And genius depends on very high intelligence in combination with a specifically adaptive Endogenous Personality characterised by powerful inner motivation and intuition:
http://geniusfamine.blogspot.co.uk
So Mouse Utopia will certainly bring-down modernity, and with it the expansion of the world population from one to seven billion. The magnitude of death and pain is appalling to contemplate.
But spiritually, ultimately, such a collapse might be the savour of the Western peoples - and certainly seems more hope-full than continuing on the present course towards ever-more complete and extreme moral and spiritual corruption.
* http://charltonteaching.blogspot.co.uk/2014/06/the-rise-and-fall-of-industrial.html
